Returns Chart

Key Stats

Net Expense Ratio Total Assets Under Management Weighted Average Dividend Yield Turnover Ratio (Generic)
0.77% 4.949B 1.16% 35.00%
1 Year Fund Level Flows 1 Year Total Returns (Daily) Annualized Total Returns Since Inception (Daily) Max Drawdown (Since Inception)
-720.79M 14.06% Upgrade Upgrade

Basic Info

Investment Strategy
The Fund seeks long-term growth of capital. The Fund invests, under normal circumstances, at least 80% of its net assets in securities of companies that the portfolio managers believe have a life science orientation. The Fund normally invests in issuers from several different countries, which may include United States.
General
Security Type Mutual Fund
Broad Asset Class Sector Equity
Broad Category Equity
Global Peer Group Equity Sector Healthcare
Peer Group Global Health/Biotechnology Funds
Global Macro Equity Industry Sector
US Macro World Sector Equity Funds
YCharts Categorization --
YCharts Benchmark --
Prospectus Objective Global Health/Biotechnology Funds
Fund Owner Firm Name Janus Henderson Investors
Broad Asset Class Benchmark Index
^MSWNTR 100.0%

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Net Fund Flows Versus Peer Group

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1M
3M
6M
YTD
1Y
3Y
5Y
10Y
 
80.00B
60.00B
40.00B
20.00B
0
-20.00B
1 Month
% Rank: 88
-502.96M Peer Group Low
85.69M Peer Group High
1 Year
% Rank: 90
-720.79M
-7.402B Peer Group Low
437.23M Peer Group High
3 Months
% Rank: 90
-1.755B Peer Group Low
426.28M Peer Group High
3 Years
% Rank: 90
-14.78B Peer Group Low
382.95M Peer Group High
6 Months
% Rank: 90
-3.495B Peer Group Low
522.62M Peer Group High
5 Years
% Rank: 90
-22.13B Peer Group Low
889.59M Peer Group High
YTD
% Rank: 90
-5.898B Peer Group Low
431.38M Peer Group High
10 Years
% Rank: 90
-41.73B Peer Group Low
856.60M Peer Group High
Date Unavailable

Performance Versus Peer Group

 
20%
15%
10%
5%
0
Name
1M
3M
YTD
1Y
3Y
5Y
10Y
15Y
Total Return (NAV)
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
Peer Group Rtn. (NAV)
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
% Rank in Peer Group (NAV)
5.0
5.0
5.0
5.0
5.0
5.0
5.0
5.0
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Annual Total Returns Versus Peers

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Name
2018
2019
2020
2021
2022
2023
2024
YTD
4.41%
29.28%
25.60%
6.86%
-2.65%
7.54%
3.63%
22.64%
-8.71%
27.67%
15.90%
21.82%
-18.14%
23.79%
18.67%
20.69%
1.21%
22.98%
12.67%
14.36%
-1.01%
5.70%
-1.53%
16.67%
6.29%
26.28%
13.35%
22.37%
-9.24%
5.98%
3.74%
9.12%
5.55%
21.97%
18.24%
20.50%
-5.50%
2.48%
2.65%
15.03%
-2.67%
33.95%
23.10%
10.01%
-11.24%
4.11%
0.39%
14.99%
As of December 05, 2025.

Fundamentals

General
Distribution Yield --
Dividend Yield TTM (12-3-25) 0.34%
30-Day SEC Yield --
7-Day SEC Yield --
Number of Holdings 100
Stock
Weighted Average PE Ratio 32.40
Weighted Average Price to Sales Ratio 9.065
Weighted Average Price to Book Ratio 9.269
Weighted Median ROE 329.3%
Weighted Median ROA -0.89%
ROI (TTM) -12.70%
Return on Investment (TTM) -12.70%
Earning Yield 0.0394
LT Debt / Shareholders Equity 3.825
Number of Equity Holdings 97
As of September 30, 2025

Growth Metrics

EPS Growth (1Y) 11.75%
EPS Growth (3Y) 9.25%
EPS Growth (5Y) 11.26%
Sales Growth (1Y) 18.06%
Sales Growth (3Y) 16.26%
Sales Growth (5Y) 17.10%
Sales per Share Growth (1Y) 54.84%
Sales per Share Growth (3Y) 14.57%
Operating Cash Flow - Growth Rate (3Y) 5.94%
As of September 30, 2025

Asset Allocation

As of September 30, 2025.
Type % Net
Cash 0.00%
Stock 98.93%
Bond 0.00%
Convertible 0.00%
Preferred 0.31%
Other 0.76%
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Top 10 Holdings

Name % Weight Price % Change
Eli Lilly & Co. 8.31% 1013.12 -0.14%
Johnson & Johnson 5.01% 201.39 -0.54%
AstraZeneca PLC 4.22% 183.28 0.00%
UnitedHealth Group, Inc. 4.20% 331.90 -0.48%
AbbVie, Inc. 3.58% 225.52 -1.39%
Abbott Laboratories 3.16% 125.60 0.16%
argenx SE 2.82% 891.23 -2.70%
Boston Scientific Corp. 2.74% 98.39 0.69%
Sanofi 2.69% 97.95 0.00%
Novartis AG 2.56% 132.65 0.17%

Fees & Availability

Fees
Actual 12B-1 Fee --
Actual Management Fee 0.64%
Administration Fee --
Maximum Front Load --
Maximum Deferred Load --
Maximum Redemption Fee 0.00%
General Availability
Available for Insurance Product No
Available for RRSP No
Purchase Details
Open to New Investors Yes
Minimum Initial Investment 0.00 None
Minimum Subsequent Investment 0.00 None

Basic Info

Investment Strategy
The Fund seeks long-term growth of capital. The Fund invests, under normal circumstances, at least 80% of its net assets in securities of companies that the portfolio managers believe have a life science orientation. The Fund normally invests in issuers from several different countries, which may include United States.
General
Security Type Mutual Fund
Broad Asset Class Sector Equity
Broad Category Equity
Global Peer Group Equity Sector Healthcare
Peer Group Global Health/Biotechnology Funds
Global Macro Equity Industry Sector
US Macro World Sector Equity Funds
YCharts Categorization --
YCharts Benchmark --
Prospectus Objective Global Health/Biotechnology Funds
Fund Owner Firm Name Janus Henderson Investors
Broad Asset Class Benchmark Index
^MSWNTR 100.0%

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Fundamentals

General
Distribution Yield --
Dividend Yield TTM (12-3-25) 0.34%
30-Day SEC Yield --
7-Day SEC Yield --
Number of Holdings 100
Stock
Weighted Average PE Ratio 32.40
Weighted Average Price to Sales Ratio 9.065
Weighted Average Price to Book Ratio 9.269
Weighted Median ROE 329.3%
Weighted Median ROA -0.89%
ROI (TTM) -12.70%
Return on Investment (TTM) -12.70%
Earning Yield 0.0394
LT Debt / Shareholders Equity 3.825
Number of Equity Holdings 97
As of September 30, 2025

Growth Metrics

EPS Growth (1Y) 11.75%
EPS Growth (3Y) 9.25%
EPS Growth (5Y) 11.26%
Sales Growth (1Y) 18.06%
Sales Growth (3Y) 16.26%
Sales Growth (5Y) 17.10%
Sales per Share Growth (1Y) 54.84%
Sales per Share Growth (3Y) 14.57%
Operating Cash Flow - Growth Rate (3Y) 5.94%
As of September 30, 2025

Fund Details

Key Dates
Inception Date 12/31/1998
Last Annual Report Date 9/30/2024
Last Prospectus Date 1/28/2025
Share Classes
JAGLX T
JFNAX A
JFNCX C
JFNNX N
JFNSX S
JNGLX D
Attributes
Index Fund --
Inverse Fund No
Leveraged Fund --
Fund of Funds No
Currency Hedged Fund --
Synthetic Replication Fund No

Top Portfolio Holders

Name % Weight
Portfolio A 5.00%
Portfolio B 3.50%
Portfolio C 2.25%
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Excel Add-In Codes

Name: =YCI("M:JFNIX", "name")
Broad Asset Class: =YCI("M:JFNIX", "broad_asset_class")
Broad Category: =YCI("M:JFNIX", "broad_category_group")
Prospectus Objective: =YCI("M:JFNIX", "prospectus_objective")
To find the codes for any of our securities and financial metrics, see our Complete Excel Reference.
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