Returns Chart

Returns Chart

Key Stats

Net Expense Ratio Total Assets Under Management Weighted Average Dividend Yield Turnover Ratio (Generic)
1.79% 5.805B 0.99% 30.00%
1 Year Fund Level Flows 1 Year Total Returns (Daily) Annualized Total Returns Since Inception (Daily) Max Drawdown (Since Inception)
-138.17M 41.69%

Basic Info

Investment Strategy
The Fund seeks long-term growth of capital. The Fund invests, under normal circumstances, at least 80% of its net assets in securities of companies that the portfolio managers believe have a life science orientation. The Fund normally invests in issuers from several different countries, which may include United States.
General
Security Type Mutual Fund
Equity Style Multi Cap Core
Broad Asset Class Sector Equity
Broad Category Equity
Global Peer Group Equity Sector Healthcare
Peer Group Global Health/Biotechnology Funds
Global Macro Equity Industry Sector
US Macro World Sector Equity Funds
YCharts Categorization --
YCharts Benchmark --
Prospectus Objective Global Health/Biotechnology Funds
Fund Owner Firm Name Janus Henderson Investors
Broad Asset Class Benchmark Index
^MSWNTR 100.0%

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Net Fund Flows Versus Peer Group

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1M
3M
6M
YTD
1Y
3Y
5Y
10Y
 
80.00B
60.00B
40.00B
20.00B
0
-20.00B
1 Month
% Rank: 15
-301.33M Peer Group Low
174.55M Peer Group High
1 Year
% Rank: 69
-138.17M
-5.126B Peer Group Low
228.89M Peer Group High
3 Months
% Rank: 58
-1.117B Peer Group Low
165.87M Peer Group High
3 Years
% Rank: 89
-16.05B Peer Group Low
279.42M Peer Group High
6 Months
% Rank: 21
-2.163B Peer Group Low
898.50M Peer Group High
5 Years
% Rank: 86
-21.85B Peer Group Low
295.73M Peer Group High
YTD
% Rank: 24
-2.518B Peer Group Low
933.08M Peer Group High
10 Years
% Rank: 83
-43.21B Peer Group Low
270.10M Peer Group High
Date Unavailable

Performance Versus Peer Group

 
20%
15%
10%
5%
0
Name
1M
3M
YTD
1Y
3Y
5Y
10Y
15Y
Total Return (NAV)
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
Peer Group Rtn. (NAV)
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
12.00%
% Rank in Peer Group (NAV)
5.0
5.0
5.0
5.0
5.0
5.0
5.0
5.0
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Annual Total Returns Versus Peers

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Name
2019
2020
2021
2022
2023
2024
2025
YTD
28.10%
24.47%
5.88%
-3.54%
6.49%
2.64%
23.68%
14.93%
27.67%
15.90%
21.82%
-18.14%
23.79%
18.67%
21.09%
13.27%
30.99%
13.58%
11.35%
-14.15%
2.23%
3.24%
14.57%
8.40%
32.25%
21.67%
9.12%
-12.41%
2.99%
-0.78%
14.65%
13.23%
24.90%
12.15%
21.19%
-10.17%
4.91%
2.71%
9.46%
6.62%
29.30%
15.05%
18.54%
-5.43%
8.22%
0.52%
14.28%
9.29%
As of August 26, 2026.

Fundamentals

General
Distribution Yield --
Dividend Yield TTM (8-25-26) 0.00%
30-Day SEC Yield --
7-Day SEC Yield --
Number of Holdings 105
Stock
Weighted Average PE Ratio 34.59
Weighted Average Price to Sales Ratio 7.986
Weighted Average Price to Book Ratio 10.08
Weighted Median ROE 526.5%
Weighted Median ROA -2.36%
Return on Investment (TTM) -0.40%
Earning Yield 0.0330
LT Debt / Shareholders Equity 0.8763
Number of Equity Holdings 100
As of June 30, 2026

Growth Metrics

EPS Growth (1Y) 30.19%
EPS Growth (3Y) 17.41%
EPS Growth (5Y) 15.05%
Sales Growth (1Y) 25.03%
Sales Growth (3Y) 22.24%
Sales Growth (5Y) 19.81%
Sales per Share Growth (1Y) 497.6%
Sales per Share Growth (3Y) 22.18%
Operating Cash Flow - Growth Rate (3Y) 8.91%
As of June 30, 2026

Asset Allocation

As of June 30, 2026.
Type % Net
Cash 0.03%
Stock 98.45%
Bond 0.00%
Convertible 0.00%
Preferred 0.66%
Other 0.85%
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Top 10 Holdings

Name % Weight Price % Change
Eli Lilly & Co. 9.41% 1233.66 -1.06%
Johnson & Johnson 7.09% 273.14 0.04%
AbbVie, Inc. 4.67% 265.79 0.48%
UnitedHealth Group, Inc. 4.54% 396.59 -0.54%
AstraZeneca PLC 3.93% 169.66 1.77%
Revolution Medicines, Inc. 3.02% 211.38 -0.09%
argenx SE 2.63% 1019.49 0.83%
Novartis AG 2.56% 159.98 1.24%
Thermo Fisher Scientific, Inc. 2.33% 628.15 -0.09%
Praxis Precision Medicines, Inc. 2.19% 368.02 -0.00%

Fees & Availability

Fees
Actual 12B-1 Fee 1.00%
Actual Management Fee 0.64%
Administration Fee --
Maximum Front Load --
Maximum Deferred Load 1.00%
Maximum Redemption Fee --
General Availability
Available for Insurance Product No
Available for RRSP No
Purchase Details
Open to New Investors Yes
Minimum Initial Investment 2500.00 None
Minimum Subsequent Investment 0.00 None

Projected Income

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Type Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul
Qualified Income
-- -- -- -- -- -- -- -- -- -- -- --
Normal
-- -- -- -- -- -- -- -- -- -- -- --
Qualified
-- -- -- -- -- -- -- -- -- -- -- --
LT Cap Gains
-- -- -- -- -- -- -- -- -- -- -- --
Ordinary Income
-- -- -- -- -- -- -- -- -- -- -- --
Non-Qual
-- -- -- -- -- -- -- -- -- -- -- --
ST Cap Gains
-- -- -- -- -- -- -- -- -- -- -- --
Interest
-- -- -- -- -- -- -- -- -- -- -- --
Tax-Exempt
-- -- -- -- -- -- -- -- -- -- -- --
ROC
-- -- -- -- -- -- -- -- -- -- -- --
Other
-- -- -- -- -- -- -- -- -- -- -- --
Total
-- -- -- -- -- -- -- -- -- -- -- --
As of July 31, 2026.

Basic Info

Investment Strategy
The Fund seeks long-term growth of capital. The Fund invests, under normal circumstances, at least 80% of its net assets in securities of companies that the portfolio managers believe have a life science orientation. The Fund normally invests in issuers from several different countries, which may include United States.
General
Security Type Mutual Fund
Equity Style Multi Cap Core
Broad Asset Class Sector Equity
Broad Category Equity
Global Peer Group Equity Sector Healthcare
Peer Group Global Health/Biotechnology Funds
Global Macro Equity Industry Sector
US Macro World Sector Equity Funds
YCharts Categorization --
YCharts Benchmark --
Prospectus Objective Global Health/Biotechnology Funds
Fund Owner Firm Name Janus Henderson Investors
Broad Asset Class Benchmark Index
^MSWNTR 100.0%

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Fundamentals

General
Distribution Yield --
Dividend Yield TTM (8-25-26) 0.00%
30-Day SEC Yield --
7-Day SEC Yield --
Number of Holdings 105
Stock
Weighted Average PE Ratio 34.59
Weighted Average Price to Sales Ratio 7.986
Weighted Average Price to Book Ratio 10.08
Weighted Median ROE 526.5%
Weighted Median ROA -2.36%
Return on Investment (TTM) -0.40%
Earning Yield 0.0330
LT Debt / Shareholders Equity 0.8763
Number of Equity Holdings 100
As of June 30, 2026

Growth Metrics

EPS Growth (1Y) 30.19%
EPS Growth (3Y) 17.41%
EPS Growth (5Y) 15.05%
Sales Growth (1Y) 25.03%
Sales Growth (3Y) 22.24%
Sales Growth (5Y) 19.81%
Sales per Share Growth (1Y) 497.6%
Sales per Share Growth (3Y) 22.18%
Operating Cash Flow - Growth Rate (3Y) 8.91%
As of June 30, 2026

Fund Details

Key Dates
Inception Date 12/31/1998
Last Annual Report Date 9/30/2025
Last Prospectus Date 1/28/2026
Share Classes
JAGLX T
JFNAX A
JFNIX Inst
JFNNX N
JFNSX S
JNGLX D
Attributes
Index Fund --
Inverse Fund No
Leveraged Fund --
Fund of Funds No
Currency Hedged Fund --
Socially Responsible Fund No

Top Portfolio Holders

Name % Weight
Portfolio A 5.00%
Portfolio B 3.50%
Portfolio C 2.25%
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Excel Add-In Codes

Name: =YCI("M:JFNCX", "name")
Broad Asset Class: =YCI("M:JFNCX", "broad_asset_class")
Broad Category: =YCI("M:JFNCX", "broad_category_group")
Prospectus Objective: =YCI("M:JFNCX", "prospectus_objective")
To find the codes for any of our securities and financial metrics, see our Complete Excel Reference.
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